TachoComb® is used as an additional hemostatic agent for surgeries performed to stop diffuse bleeding in cases when the standard approaches are not effective. The article considers the possibility of the use of TachoComb® agent for patients with endometrial cancer during laparoscopic interventions.
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The paper evaluates the feasibility of surgery as the only treatment modality in gonadal germ cell tumors. The factors which infl uence the outcomes of the treatment are studied.
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Objective. The objective of the work is to study the role of secondary cytoreductive surgeryfor the treatment of recurrent ovarian cancer.
Materials and Methods. The work analyzes the results of the treatment of 101 primary patients with stage IIB–IV ovarian cancer who underwent examination and treatment in the Department of Surgery № 8 of the Scientifi c Research Institute of Clinical Oncology of the Federal State Budgetary Institution N.N. Blokhin Cancer Research Center of the Russian Academy of Medical Sciences for the period from 1998 to 2007 and continued to be under observation and treatment right until 2012 inclusive. The median observation period was 31,6 months (0,7–175,1).
Results. The frequency of secondary complete cytoreductive surgeries in the study was 27,8% of all patients with platinumsensitive recurrent cancer and 62,5% of all patients who had underwent surgery for recurrent ovarian cancer. The median overall recurrence-free survival of patients who had underwent complete cytoreductive surgery reached 89 months, and the median recurrence-free period – 23,4 months.
Conclusions. The study confi rmed the feasibility of secondary cytoreductive surgeries in patients with locally-advanced platinum-sensitive recurrent ovarian cancer aimed at increase of longevity.
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The article summarises the particularities of the diagnosis, surgical treatment and management of ovarian tumors and tumor-like lesions of the ovaries in pregnant women. The authors outlined the basic principles of conservative or surgical management and proved high effi ciency of laparascopic method in surgical intervention during the fi rst and second trimester of pregnancy.
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In our opinion, granulosa cell tumor (GCT) of the ovary is the most interesting one of all stromal cell tumors. Although the incidence of this type of tumor is low, however the management of patients with this pathology pose a signifi cant challenge for oncologists. Low sensitivity to medical treatment and radiation therapy, uncertainty about the effectiveness of hormonal treatment and a number of different features and characteristics of the tumor — this is a range of problems associated with granulose cell tumor of the ovary. A great deal of issues are related to the reproductive function of patients who underwent organ-preserving operations at the early stages of the process. The article discusses and covers the questions regarding an early primary granulosa cell tumor (GCT) of the ovary and its recurrence, the extent of surgical intervention and medical treatment, some other unresolved problems concerning innovative methods of therapy.
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Objective. The objective is to study the condition of the fi mbrial portion of fallopian tubes in women of reproductive age who have benign tumors and tumor-like lesion of the ovaries.
Materials and Methods. The ultrastructure of microbiopsies of the fi mbrial portion of fallopian tubes obtained from 63 patients of reproductive age who had benign tumors and tumor-like lesions of the ovary was analyzed. The examination was performed using a transmission and scanning electron microscopic method.
Results. Apparent morphofunctional disorders which were characterized by the presence of atypical fi mbriae with multiple axonemas and structural anomalies of intermediary transition zone of fi mbriae were detected in half of the patients.
Conclusions. It can be suggested that the identifi ed ultrastructural changes play a signifi cant role in etiopathogenesis of benign ovarian tumours. The question of whether the anomalies of transition zone of atypical fi mbriae could be a genetically induced form of ciliopathies is being discussed.
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Objective. The objective of the work is to study the role and place of microwave radiothermometry as a method which permits to objectively evaluate thermal changes occurring in tumor tissues in the course of neoadjuvant treatment and to predict its effectiveness.
Materials and Methods. To quantify the effectiveness of the treatment using radiothermometric diagnosis, the total degree obtained as a result of summing up the changes in the parameters under investigation, was determined. Two parameters were examined: internal temperature in the projection image of the tumor and skin thermoassymetry (the difference in skin temperatures in the projection image of the tumor and in the corresponding area of a healthy breast). A growth of the values of these parameters indicate the progression of the disease.
Results. Based on the analysis conducted it can be concluded that the total degree correlates with the degree of severity of clinical pathomorphosis — the greater the total degree, the greater the severity of pathomorphosis. The total degree can be used to evaluate the effi ciency of neoadjuvant therapy and to serve as one of its prognostic indicators.
Conclusions. Microwave thermometry allows us to estimate the thermal changes both in breast tissue and on its surface. Owing to its simplicity in research, non-invasiveness and safety microwave radiothermometry can be a promising method of assessment of the effi ciency of neoadjuvant treatment for breast cancer.
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The present literature overview analyzes pathogenesis of anaemia development, evaluates it consequences for the effectiveness of anti-tumor treatment, proves the feasibility of performing differential diagnosis of anaemic syndrome and comprehensively discusses the problem of iron-defi ciency anaemia and the methods of its correction using the modern pharmaceutical agents.
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