The article presents the results of the authors’ own research and the most compelling literature data, certifying that the key positive regulator of neoangiogenesis — vascular endothelial growth factor (VEGF) — is a clinically signifi cant prognostic factor in different types of oncologic diseases and is a target for the modern drugs with various mechanisms of action as well. The role of VEGF as a serological marker for the diagnosis and monitoring requires further investigation.
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The article presents different opinions on feasibility of performing preventive adnexectomy together with hysterectomy in patients with benign uterine pathology.
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The pathogenesis of the development of endometriosis and epithelial ovarian tumors still remains a mystery. The identifi ed common mechanisms of the progression of both pathologies confi rm a close link between endometriosis and the development of some types of ovarian cancer.
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Objective of the study: to develop methodological approaches to the prevention of recurrence of HPV-associated cervical cancer.
Materials and methods: photodynamic therapy is performed in 40 patients aged from 22 to 46 years old (median 33 years) with an early cervical cancer after organ-preserving surgery — high conization and trachelectomy (cervicectomy): carcinoma in situ (n = 18) and cervical cancer stage 1A1 (n = 22). Identifi cation and differentiation of HPV DNA is performed using polymerase chain reaction technique. Alasens dose (20% ointment) was 0,1 mg/cm2, exposure time — 6 hours. Light source — laser diode «LFT-630-01-BIOSPEC».
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The article presents the statement of international consensus on the prevention of venous thromboembolism in cancer patients. Groups of patients with risk factors for venous thromboembolism (VTE) are identifi ed and guidelines for the prevention of this pathology in cancer patients are given.
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The article states the indications and principles of prescribing menopausal hormone therapy, focuses on the oncological risks involved. The article also raises an urgent question regarding the possibility to use menopausal hormone therapy for women from the groups of risk of developing hereditary cancer (carriers of BRCA1/2 gene mutations) after preventive surgery.
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Cancer of unknown primary (CUP) is a term used to describe a cancer that is determined to be at the metastatic stage at the time of diagnosis, but a primary tumor can neither be identifi ed based on medical case history (anamnesis) nor on examination. Unique biology of such tumors remains unknown, however, the identifi cation of specifi c CUP-related molecular and biological divergences may contribute to the development of more effective therapy of patients.
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The article presents the general characteristics of rectovaginal fi stulae, the techniques of their surgical management. Among patients with rectovaginal fi stulae cancer patients are the most diffi cult groups. One of the causes of fi stulae formation in such patients is locally-advanced tumor process in pelvis. Fistulae in cancer may be not only a consequence of the progression of underlying disease, but be related to the complication of cancer treatment as well, most often — of radiation therapy.
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Adhesive disease of the abdominal cavity is a common condition worldwide. The article gives a defi nition of this disease, considers the principal mechanisms of its etiopathogenesis and presents the experience of the use of anti-adhesive barrier CollaGUARD in patients with gynecologic cancers.
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